Transcriptome analyses of the cortex and white matter of focal cortical dysplasia type II: Insights into pathophysiology and tissue characterization.

ABSTRACT:

Introduction

Focal cortical dysplasia (FCD) is a common cause of pharmacoresistant epilepsy. According to the 2022 International League Against Epilepsy classification, FCD type II is characterized by dysmorphic neurons (IIa and IIb) and may be associated with balloon cells (IIb). We present a multicentric study to evaluate the transcriptomes of the gray and white matters of surgical FCD type II specimens. We aimed to contribute to pathophysiology and tissue characterization.

Methods

We investigated FCD II (a and b) and control samples by performing RNA-sequencing followed by immunohistochemical validation employing digital analyses.

Results

We found 342 and 399 transcripts differentially expressed in the gray matter of IIa and IIb lesions compared to controls, respec

SUBMITTER: Assis-Mendonca GR 

PROVIDER: S-EPMC10050872 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature