Comparative Effectiveness and Safety of Oral Anticoagulants by Dementia Status in Older Patients With Atrial Fibrillation.

ABSTRACT:

Importance

The development of an optimal stroke prevention strategy, including the use of oral anticoagulant (OAC) therapy, is particularly important for patients with atrial fibrillation (AF) who are living with dementia, a condition that increases the risk of adverse outcomes. However, data on the role of dementia in the safety and effectiveness of OACs are limited.

Objective

To assess the comparative safety and effectiveness of specific OACs by dementia status among older patients with AF.

Design, setting, and participants

This retrospective comparative effectiveness study used 1:1 propensity score matching among 1 160 462 patients 65 years or older with AF. Data were obtained from the Optum Clinformatics Data Mart (January 1, 2013, to June 30, 2021), IBM MarketSca

SUBMITTER: Lin KJ 

PROVIDER: S-EPMC10051113 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature