Dataset Information

Antibodies to Combat Fungal Infections: Development Strategies and Progress.

ABSTRACT: The finding that some mAbs are antifungal suggests that antibody immunity may play a key role in the defense of the host against mycotic infections. The discovery of antibodies that guard against fungi is a significant advancement because it gives rise to the possibility of developing vaccinations that trigger protective antibody immunity. These vaccines might work by inducing antibody opsonins that improve the function of non-specific (such as neutrophils, macrophages, and NK cells) and specific (such as lymphocyte) cell-mediated immunity and stop or aid in eradicating fungus infections. The ability of antibodies to defend against fungi has been demonstrated by using monoclonal antibody technology to reconsider the function of antibody immunity. The next step is to develop vaccines that induce protective antibody immunity and to comprehend the mechanisms through which antibodies mediate protective effects against fungus.

SUBMITTER: Rabaan AA

PROVIDER: S-EPMC10051215 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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Antibodies to Combat Fungal Infections: Development Strategies and Progress.

Rabaan Ali A AA Alfaraj Amal H AH Alshengeti Amer A Alawfi Abdulsalam A Alwarthan Sara S Alhajri Mashael M Al-Najjar Amal H AH Al Fares Mona A MA Najim Mustafa A MA Almuthree Souad A SA AlShurbaji Sultan T ST Alofi Fadwa S FS AlShehail Bashayer M BM AlYuosof Buthina B Alynbiawi Ahlam A Alzayer Suha A SA Al Kaabi Nawal N Abduljabbar Wesam A WA Bukhary Zakiyah A ZA Bueid Ahmed S AS

Microorganisms 20230306 3

The finding that some mAbs are antifungal suggests that antibody immunity may play a key role in the defense of the host against mycotic infections. The discovery of antibodies that guard against fungi is a significant advancement because it gives rise to the possibility of developing vaccinations that trigger protective antibody immunity. These vaccines might work by inducing antibody opsonins that improve the function of non-specific (such as neutrophils, macrophages, and NK cells) and specifi ...[more]

PMID: 36985244

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Project description:Camellia oleifera Abel, a woody oil plant, that is endemic to China. Tea oil, also referred to as "oriental olive oil," is a superior quality plant-based cooking oil. The production of tea oil accounts for 8% of the total edible vegetable oil production in the country. Since 2022, the annual output value of C. oleifera industry has exceeded 100 billion yuan, making it one of the major economic contributors to China's rural revitalization development strategy. In recent years, demand and production have grown in parallel. However, this has led to an increase in the incidence levels of pest and diseases. Pests and diseases significantly reduce the quality and yield of C. oleifera. C. oleifera diseases are mainly caused by pathogenic fungi. C. oleifera anthracnose, soft rot, leaf spot, coal stain, leaf gall disease, and root rot are the most important fungal diseases affecting the C. oleifera industry. However, the same disease may be caused by different pathogenic fungi. C. oleifera can be found in half of China and is found in several climatic zones. The geographical distribution of woody plant diseases is consistent with the distribution of the tree species and the ecology of the range, which also results in a highly complex distribution of fungal diseases of C. oleifera. The management of fungal diseases in C. oleifera is extremely challenging due to the variety of pathogenic fungal species, multiple routes of transmission, the lack of resistant plants, and the environmental safety of chemical measures. The optimal strategy for addressing fungal diseases in C. oleifera is to develop and apply an integrated disease management plan. This review provides a brief overview of the pathogenic species, pathogenesis, pathogenesis, geographical distribution, current management strategies, and potentially new methods of C. oleifera fungal diseases, to provide direction for the development of comprehensive management measures for C. oleifera fungal diseases in the future.

Dataset Information

Antibodies to Combat Fungal Infections: Development Strategies and Progress.

Publications

Antibodies to Combat Fungal Infections: Development Strategies and Progress.

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