Blackberry-Loaded AgNPs Attenuate Hepatic Ischemia/Reperfusion Injury via PI3K/Akt/mTOR Pathway.

ABSTRACT: Liver ischemia-reperfusion injury (IRI) is a pathophysiological insult that often occurs during liver surgery. Blackberry leaves are known for their anti-inflammatory and antioxidant activities.

Aims

To achieve site-specific delivery of blackberry leaves extract (BBE) loaded AgNPs to the hepatocyte in IRI and to verify possible molecular mechanisms.

Methods

IRI was induced in male Wister rats. Liver injury, hepatic histology, oxidative stress markers, hepatic expression of apoptosis-related proteins were evaluated. Non-targeted metabolomics for chemical characterization of blackberry leaves extract was performed.

Key findings

Pre-treatment with BBE protected against the deterioration caused by I/R, depicted by a significant improvement of liver functions

SUBMITTER: Fathi AM 

PROVIDER: S-EPMC10051224 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature