Characterization of Virulent T4-Like Acinetobacter baumannii Bacteriophages DLP1 and DLP2.

ABSTRACT: The world is currently facing a global health crisis due to the rapid increase in antimicrobial-resistant bacterial infections. One of the most concerning pathogens is Acinetobacter baumannii, which is listed as a Priority 1 pathogen by the World Health Organization. This Gram-negative bacterium has many intrinsic antibiotic resistance mechanisms and the ability to quickly acquire new resistance determinants from its environment. A limited number of effective antibiotics against this pathogen complicates the treatment of A. baumannii infections. A potential treatment option that is rapidly gaining interest is "phage therapy", or the clinical application of bacteriophages to selectively kill bacteria. The myoviruses DLP1 and DLP2 (vB_AbaM-DLP_1 and vB_AbaM-DLP_2, respectively)

SUBMITTER: Peters DL 

PROVIDER: S-EPMC10051250 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature