Management of Tuberculosis Infection: Current Situation, Recent Developments and Operational Challenges.

ABSTRACT: Tuberculosis infection (TBI) is defined as a state of infection in which individuals host live Mycobacterium tuberculosis with or without clinical signs of active TB. It is now understood as a dynamic process covering a spectrum of responses to infection resulting from the interaction between the TB bacilli and the host immune system. The global burden of TBI is about one-quarter of the world's population, representing a reservoir of approximately 2 billion people. On average, 5-10% of people who are infected will develop TB disease over the course of their lives, but this risk is enhanced in a series of conditions, such as co-infection with HIV. The End-TB strategy promotes the programmatic management of TBI as a crucial endeavor to achieving global targets to end the TB epidemic.

SUBMITTER: Agbota G 

PROVIDER: S-EPMC10051832 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature