Promising Strategy of mPTP Modulation in Cancer Therapy: An Emerging Progress and Future Insight.

ABSTRACT: Cancer has been progressively a major global health concern. With this developing global concern, cancer determent is one of the most significant public health challenges of this era. To date, the scientific community undoubtedly highlights mitochondrial dysfunction as a hallmark of cancer cells. Permeabilization of the mitochondrial membranes has been implicated as the most considerable footprint in apoptosis-mediated cancer cell death. Under the condition of mitochondrial calcium overload, exclusively mediated by oxidative stress, an opening of a nonspecific channel with a well-defined diameter in mitochondrial membrane allows free exchange between the mitochondrial matrix and the extra mitochondrial cytosol of solutes and proteins up to 1.5 kDa. Such a channel/nonspecific pore is recogn

SUBMITTER: Waseem M 

PROVIDER: S-EPMC10051994 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature