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Novel Synthesis of Dihydroisoxazoles by p-TsOH-Participated 1,3-Dipolar Cycloaddition of Dipolarophiles withα-Nitroketones.

ABSTRACT: This article reports in detail a method for the synthesis of 3-benzoxoxazoline by the reaction of alkenes (alkynes) and a variety of α-nitroketones in the presence of p-TsOH. The scope of alkenes is broad, including different alkenes and the alkyne. This reaction provides a convenient and efficient synthetic method of 3-benzoylisoxazolines.

SUBMITTER: Yang C

PROVIDER: S-EPMC10052018 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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Novel Synthesis of Dihydroisoxazoles by <i>p</i>-TsOH-Participated 1,3-Dipolar Cycloaddition of Dipolarophiles withα-Nitroketones.

Yang Caiyun C Hu Sirou S Pan Xinhui X Yang Ke K Zhang Ke K Liu Qingguang Q Xin Xiaobing X Li Jie J Wang Jinhui J Yang Xiaoda X

Molecules (Basel, Switzerland) 20230311 6

This article reports in detail a method for the synthesis of 3-benzoxoxazoline by the reaction of alkenes (alkynes) and a variety of α-nitroketones in the presence of <i>p</i>-TsOH. The scope of alkenes is broad, including different alkenes and the alkyne. This reaction provides a convenient and efficient synthetic method of 3-benzoylisoxazolines. ...[more]

PMID: 36985536

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