Enhanced Remdesivir Analogues to Target SARS-CoV-2.

ABSTRACT: We report the short synthesis of novel C-nucleoside Remdesivir analogues, their cytotoxicity and an in vitro evaluation against SARS-CoV-2 (CoV2). The described compounds are nucleoside analogues bearing a nitrogen heterocycle as purine analogues. The hybrid structures described herein are designed to enhance the anti-CoV2 activity of Remdesivir. The compounds were evaluated for their cytotoxicity and their anti-CoV2 effect. We discuss the impact of combining both sugar and base modifications on the biological activities of these compounds, their lack of cytotoxicity and their antiviral efficacy.

SUBMITTER: Majima R 

PROVIDER: S-EPMC10052049 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature