Influence of Canonical and Non-Canonical IFNLR1 Isoform Expression on Interferon Lambda Signaling.

ABSTRACT: Interferon lambdas (IFNLs) are innate immune cytokines that induce antiviral cellular responses by signaling through a heterodimer composed of IL10RB and the interferon lambda receptor 1 (IFNLR1). Multiple IFNLR1 transcriptional variants are expressed in vivo and are predicted to encode distinct protein isoforms whose function is not fully established. IFNLR1 isoform 1 has the highest relative transcriptional expression and encodes the full-length functional form that supports canonical IFNL signaling. IFNLR1 isoforms 2 and 3 have lower relative expression and are predicted to encode signaling-defective proteins. To gain insight into IFNLR1 function and regulation, we explored how altering relative expression of IFNLR1 isoforms influenced the cellular response to IFNLs

SUBMITTER: Evans JG 

PROVIDER: S-EPMC10052089 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature