Extracellular Vesicles as Drug Delivery Systems in Organ Transplantation: The Next Frontier.

ABSTRACT: Extracellular vesicles are lipid bilayer-delimited nanoparticles excreted into the extracellular space by all cells. They carry a cargo rich in proteins, lipids and DNA, as well as a full complement of RNA species, which they deliver to recipient cells to induce downstream signalling, and they play a key role in many physiological and pathological processes. There is evidence that native and hybrid EVs may be used as effective drug delivery systems, with their intrinsic ability to protect and deliver a functional cargo by utilising endogenous cellular mechanisms making them attractive as therapeutics. Organ transplantation is the gold standard for treatment for suitable patients with end-stage organ failure. However, significant challenges still remain in organ transplantation; prevention

SUBMITTER: Spiers HVM 

PROVIDER: S-EPMC10052210 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature