Supramolecular Recognition of Cytidine Phosphate in Nucleotides and RNA Sequences.

ABSTRACT: Supramolecular recognition of nucleotides would enable manipulating crucial biochemical pathways like transcription and translation directly and with high precision. Therefore, it offers great promise in medicinal applications, not least in treating cancer or viral infections. This work presents a universal supramolecular approach to target nucleoside phosphates in nucleotides and RNA. The artificial active site in new receptors simultaneously realizes several binding and sensing mechanisms: encapsulation of a nucleobase via dispersion and hydrogen bonding interactions, recognition of the phosphate residue, and a self-reporting feature-"turn-on" fluorescence. Key to the high selectivity is the conscious separation of phosphate- and nucleobase-binding sites by introducing specific spacers i

SUBMITTER: Morozov BS 

PROVIDER: S-EPMC10052242 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature