Exploiting a targeted resistome sequencing approach in assessing antimicrobial resistance in retail foods.

ABSTRACT:

Background

With the escalating risk of antimicrobial resistance (AMR), there are limited analytical options available that can comprehensively assess the burden of AMR carried by clinical/environmental samples. Food can be a potential source of AMR bacteria for humans, but its significance in driving the clinical spread of AMR remains unclear, largely due to the lack of holistic-yet-sensitive tools for surveillance and evaluation. Metagenomics is a culture-independent approach well suited for uncovering genetic determinants of defined microbial traits, such as AMR, present within unknown bacterial communities. Despite its popularity, the conventional approach of non-selectively sequencing a sample's metagenome (namely, shotgun-metagenomics) has several technical drawbacks that lead

SUBMITTER: Shay JA 

PROVIDER: S-EPMC10052294 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature