Effectiveness of Molnupiravir and Nirmatrelvir-Ritonavir in Hospitalized Patients With COVID-19 : A Target Trial Emulation Study.

ABSTRACT:

Background

Whether hospitalized patients benefit from COVID-19 oral antivirals is uncertain.

Objective

To examine the real-world effectiveness of molnupiravir and nirmatrelvir-ritonavir in hospitalized patients with COVID-19 during the Omicron outbreak.

Design

Target trial emulation study.

Setting

Electronic health databases in Hong Kong.

Participants

The molnupiravir emulated trial included hospitalized patients with COVID-19 aged 18 years or older between 26 February and 18 July 2022 (n = 16 495). The nirmatrelvir-ritonavir emulated trial included hospitalized patients with COVID-19 aged 18 years or older between 16 March and 18 July 2022 (n = 7119).

Intervention

Initiation of molnupiravir or nirmatrelvir-ritonavir within 5 days of

SUBMITTER: Wan EYF 

PROVIDER: S-EPMC10052319 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature