Chemical Constituents of the Mushroom Dictyophora indusiata and Their Anti-Inflammatory Activities.

ABSTRACT: As an edible and medicinal fungus, Dictyophora indusiata is well-known for its morphological elegance, distinctive taste, high nutritional value, and therapeutic properties. In this study, eighteen compounds (1-18) were isolated and identified from the ethanolic extract of D. indusiata; four (1-4) were previously undescribed. Their molecular structures and absolute configurations were determined via a comprehensive analysis of spectroscopic data (1D/2D NMR, HRESIMS, ECD, and XRD). Seven isolated compounds were examined for their anti-inflammatory activities using an in vitro model of lipopolysaccharide (LPS)-simulated BV-2 microglial cells. Compound 3 displayed the strongest inhibitory effect on tumor necrosis factor-α (TNF-α) expression, wi

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10052543 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature