A Simple Method for Robust and Accurate Intrinsic Subtyping of Breast Cancer.

ABSTRACT:

Motivation

The PAM50 signature/method is widely used for intrinsic subtyping of breast cancer samples. However, depending on the number and composition of the samples included in a cohort, the method may assign different subtypes to the same sample. This lack of robustness is mainly due to the fact that PAM50 subtracts a reference profile, which is computed using all samples in the cohort, from each sample before classification. In this paper we propose modifications to PAM50 to develop a simple and robust single-sample classifier, called MPAM50, for intrinsic subtyping of breast cancer. Like PAM50, the modified method uses a nearest centroid approach for classification, but the centroids are computed differently, and the distances to the centroids are determined using an alternati

SUBMITTER: Hamaneh M 

PROVIDER: S-EPMC10052604 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature