Identification of a Biomarker Panel for Diagnosis of Early Childhood Caries Using Salivary Metabolic Profile.

ABSTRACT: Several studies have demonstrated that nuclear magnetic resonance (NMR) metabolic profiles can differentiate patients with caries from healthy individuals; however, these studies only identified individual metabolites. The present study aimed to identify a salivary metabolite biomarker panel for the diagnosis of early childhood caries (ECC). Saliva samples from children with and without caries were analyzed using NMR spectroscopy. Multivariate and univariate analyses were performed to identify the discriminating metabolites. Selected metabolites were further evaluated and used to detect ECC. The saliva samples of children with ECC were characterized based on the increased levels of formate, glycerophosphocholine, and lactate and reduced levels of alanine, glycine, isoleucine, lysine, proli

SUBMITTER: Kim S 

PROVIDER: S-EPMC10052657 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature