Cardiovascular disease-linked plasma proteins are mainly associated with lung volume.

ABSTRACT:

Background

Epidemiological studies have shown that impaired lung function is common and associated with increased risk of cardiovascular disease. Increased levels of several inflammatory and cardiovascular disease-related plasma proteins have been associated with impaired lung function. The aim was to study the association between plasma proteomics and forced expiratory volume in 1 s (FEV₁), forced vital capacity (FVC) and FEV₁/FVC ratio.

Methods

We used a discovery and replication approach in two community-based cohorts, EpiHealth and the Malmö Offspring Study (total n=2874), to cross-sectionally study 242 cardiovascular disease- and metabolism-linked proteins in relation to FEV₁, FVC (both % predicted) and FEV₁/FVC ratio. A false

SUBMITTER: Rydell A 

PROVIDER: S-EPMC10052712 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature