Interstitial lung abnormalities are associated with decreased mean telomere length.

ABSTRACT:

Background

Interstitial lung abnormalities (ILA) share many features with idiopathic pulmonary fibrosis; however, it is not known if ILA are associated with decreased mean telomere length (MTL).

Methods

Telomere length was measured with quantitative PCR in the Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene) and Age Gene/Environment Susceptibility Reykjavik (AGES-Reykjavik) cohorts and Southern blot analysis was used in the Framingham Heart Study (FHS). Logistic and linear regression were used to assess the association between ILA and MTL; Cox proportional hazards models were used to assess the association between MTL and mortality.

Results

In all three cohorts, ILA were associated with decreased MTL. In the COPDGene and AGES-Reykjavik cohorts,

SUBMITTER: Putman RK 

PROVIDER: S-EPMC10052789 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature