Gram-negative bacteria resist antimicrobial agents by a DzrR-mediated envelope stress response.

ABSTRACT:

Background

Envelope stress responses (ESRs) are critical for adaptive resistance of Gram-negative bacteria to envelope-targeting antimicrobial agents. However, ESRs are poorly defined in a large number of well-known plant and human pathogens. Dickeya oryzae can withstand a high level of self-produced envelope-targeting antimicrobial agents zeamines through a zeamine-stimulated RND efflux pump DesABC. Here, we unraveled the mechanism of D. oryzae response to zeamines and determined the distribution and function of this novel ESR in a variety of important plant and human pathogens.

Results

In this study, we documented that a two-component system regulator DzrR of D. oryzae EC1 mediates ESR in the presence of envelope-targeting antimicrobial agents. DzrR was found modulating ba

SUBMITTER: Liang Z 

PROVIDER: S-EPMC10052836 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature