Association of regular glucosamine use with incident dementia: evidence from a longitudinal cohort and Mendelian randomization study.

ABSTRACT:

Background

Emerging data suggests the neuroprotective and anti-neuroinflammatory effects of glucosamine. We aimed to examine the association between regular glucosamine use and risk of incident dementia, including dementia subtypes.

Methods

We conducted large-scale observational and two-sample Mendelian randomization (MR) analyses. Participants in UK Biobank having accessible data for dementia incidence and who did not have dementia at baseline were included in the prospective cohort. Through the Cox proportional hazard model, we examined the risks of incident all-cause dementia, Alzheimer's disease (AD), and vascular dementia among glucosamine users and non-users. To further test the causal association between glucosamine use and dementia, we conducted a 2-sample MR utilizi

SUBMITTER: Zheng J 

PROVIDER: S-EPMC10052856 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature