Structural and Functional Characterization of the Newly Designed Antimicrobial Peptide Crabrolin21.

ABSTRACT: (1) Background: antimicrobial resistance is becoming a dramatic problem for public health, and the design of new antimicrobial agents is an active research area. (2) Methods: based on our previous work, we designed an improved version of the crabrolin peptide and characterized its functional and structural properties with a wide range of techniques. (3) Results: the newly designed peptide, crabrolin21, is much more active than the previous ones and shows specific selectivity towards bacterial cells. (4) Conclusions: crabrolin21 shows interesting properties and deserves further studies.

SUBMITTER: Cantini F 

PROVIDER: S-EPMC10053045 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature