Intravenous iron infusion in patients with heart failure: a systematic review and study-level meta-analysis.

ABSTRACT:

Aims

There is considerable variability in the effect of intravenous iron on hard cardiovascular (CV)-related outcomes in patients with heart failure (HF) in randomized controlled trials (RCTs). We use a meta-analytic approach to analyse data from existing RCTs to derive a more robust estimate of the effect size of intravenous iron infusion on CV-related outcomes in patients with HF.

Method and results

PubMed/Medline was searched using the following terms: ('intravenous' and 'iron' and 'heart failure') from inception till 6 November 2022 for RCTs comparing intravenous iron infusion with placebo or standard of care in patients with HF and iron deficiency. Outcomes were the composite of CV mortality and first hospitalization for HF; all-cause mortality; CV mortality; first hosp

SUBMITTER: Salah HM 

PROVIDER: S-EPMC10053151 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature