Effect of mortality in cost-effectiveness modeling of disease-modifying treatment for Alzheimer's disease.

ABSTRACT:

Introduction

We examined (1) the magnitude of mortality attributed to Alzheimer's disease (AD), and (2) the effect of mortality in cost-effectiveness modeling of hypothetical disease-modifying treatment (DMT) in AD.

Method

Data were derived from Swedish Dementia Registry (N = 39,308). Mortality was analyzed with survival analysis and multinomial logistic regression. A Markov microsimulation model was used to model the cost effectiveness of DMT using routine care as a comparator. Three scenarios were simulated: (1) indirect effect, (2) no effect on overall mortality, (3) indirect effect on AD-related mortality.

Results

Overall mortality increased with cognitive decline, age, male sex, number of medications used, and lower body mass index. Nearly all cause-specif

SUBMITTER: Aye S 

PROVIDER: S-EPMC10053186 | biostudies-literature | 2023 Jan-Mar

REPOSITORIES: biostudies-literature