HINT2 deficiency deteriorates oxidative stress in a mouse model of myocardial infarction.

ABSTRACT:

Aims

Myocardial infarction (MI) is one of the serious diseases with great mortality over the world. Myocardial mitochondrial oxidative stress has been implicated as a key player in MI. The histidine triad nucleotide-binding protein 2 (HINT2) is a nucleotide hydrolase and transferase located in mitochondria. HINT2 has multiple functions such as regulating mitochondrial lipid metabolism and respiration and glucose homeostasis. Although HINT2 has been shown to protect against MI, the underlying mechanisms were not fully elucidated. In this study, the effects of HINT2 on oxidative stress during MI were explored.

Methods and results

MI mouse models in both wild-type and HINT2-deficient mice were established. The expression of HINT2 in HINT2-deficient mice was determined by quanti

SUBMITTER: Li F 

PROVIDER: S-EPMC10053249 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature