Receptor autoantibodies: Associations with cardiac markers, histology, and function in human non-ischaemic heart failure.

ABSTRACT:

Aims

A causal link between non-ischaemic heart failure (HF) and humoral autoimmunity against G-protein-coupled receptors (GPCR) remains unclear except for Chagas' cardiomyopathy. Uncertainty arises from ambiguous reports on incidences of GPCR autoantibodies, spurious correlations of autoantibody levels with disease activity, and lack of standardization and validation of measuring procedures for putatively cardio-pathogenic GPCR autoantibodies. Here, we use validated and certified immune assays presenting native receptors as binding targets. We compared candidate GPCR autoantibody species between HF patients and healthy controls and tested associations of serum autoantibody levels with serological, haemodynamic, metabolic, and functional parameters in HF.

Methods

Ninety-five

SUBMITTER: Zweck E 

PROVIDER: S-EPMC10053254 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature