Mean corpuscular haemoglobin concentration and outcomes in heart failure with preserved ejection fraction.

ABSTRACT:

Aims

This study aims to evaluate the prognostic value of mean corpuscular haemoglobin concentration (MCHC) on clinical outcomes in patients with heart failure with preserved ejection fraction (HFpEF).

Methods and results

We analysed HFpEF participants from the Americas in the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) trial with available baseline data (n = 1747). Patients were grouped into hypochromia or non-hypochromia group according to a MCHC cut-off level of 330 g/L. Cox proportional hazard model was used to explore the prognostic value of hypochromia on the long-term clinical outcomes (the primary endpoint [composite of cardiovascular mortality, HF hospitalization and aborted cardiac arrest], any-cause and HF hospitali

SUBMITTER: Choy M 

PROVIDER: S-EPMC10053270 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature