Lung diffusion capacity correlates with pre-implant pulmonary hypertension and predicts outcome after LVAD implantation.

ABSTRACT:

Aims

Diffusing capacity of the lung for carbon monoxide (DL_CO ) reduction is common in heart failure (HF) and is associated with a worse prognosis. Correlations between DL_CO and pulmonary hypertension (PH) are unclear, and published data are conflicting; it has been shown that DL_CO impairment may persist or even worsen after normalization of pulmonary pressures following left ventricle assist device (LVAD) implantation, maybe reflecting persistent pulmonary damage. We aimed to investigate the impact of pre-implant DL_CO and central haemodynamics on outcome in patients with advanced HF implanted with a LVAD.

Methods and results

We retrospectively analysed pre-implant and post-implant data from 42 patients implanted with a LVAD at our

SUBMITTER: Macera F 

PROVIDER: S-EPMC10053279 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature