Biomarkers to Predict Lethal Radiation Injury to the Rat Lung.

ABSTRACT: Currently, there are no biomarkers to predict lethal lung injury by radiation. Since it is not ethical to irradiate humans, animal models must be used to identify biomarkers. Injury to the female WAG/RijCmcr rat has been well-characterized after exposure to eight doses of whole thorax irradiation: 0-, 5-, 10-, 11-, 12-, 13-, 14- and 15-Gy. End points such as SPECT imaging of the lung using molecular probes, measurement of circulating blood cells and specific miRNA have been shown to change after radiation. Our goal was to use these changes to predict lethal lung injury in the rat model, 2 weeks post-irradiation, before any symptoms manifest and after which a countermeasure can be given to enhance survival. SPECT imaging with ^99mTc-MAA identified a decrease in perfusion in the lu

SUBMITTER: Medhora M 

PROVIDER: S-EPMC10053311 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature