Membraneless Compartmentalization of Nuclear Assembly Sites during Murine Cytomegalovirus Infection.

ABSTRACT: Extensive reorganization of infected cells and the formation of large structures known as the nuclear replication compartment (RC) and cytoplasmic assembly compartment (AC) is a hallmark of beta-herpesvirus infection. These restructurings rely on extensive compartmentalization of the processes that make up the virus manufacturing chain. Compartmentalization of the nuclear processes during murine cytomegalovirus (MCMV) infection is not well described. In this study, we visualized five viral proteins (pIE1, pE1, pM25, pm48.2, and pM57) and replicated viral DNA to reveal the nuclear events during MCMV infection. As expected, these events can be matched with those described for other beta and alpha herpesviruses and contribute to the overall picture of herpesvirus assembly. Imaging showed that

SUBMITTER: Mahmutefendic Lucin H 

PROVIDER: S-EPMC10053344 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature