Oral Administration as a Potential Alternative for the Delivery of Small Extracellular Vesicles.

ABSTRACT: Small extracellular vesicles (sEVs) have burst into biomedicine as a natural therapeutic alternative for different diseases. Considered nanocarriers of biological origin, various studies have demonstrated the feasibility of their systemic administration, even with repeated doses. However, despite being the preferred route of physicians and patients, little is known about the clinical use of sEVs in oral administration. Different reports show that sEVs can resist the degradative conditions of the gastrointestinal tract after oral administration, accumulating regionally in the intestine, where they are absorbed for systemic biodistribution. Notably, observations demonstrate the efficacy of using sEVs as a nanocarrier system for a therapeutic payload to obtain a desired biological (therapeuti

SUBMITTER: Donoso-Meneses D 

PROVIDER: S-EPMC10053447 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature