Antimicrobial Peptides: Avant-Garde Antifungal Agents to Fight against Medically Important Candida Species.

ABSTRACT: Expanding the antifungal drug arsenal for treating Candida infections is crucial in this era of the rising life expectancy of patients with immunosuppression and comorbidities. Infections caused by Candida species are on the rise, including those caused by multidrug-resistant strains or species, and the list of antifungals approved for the treatment of these infections is still limited. Antimicrobial peptides (AMPs) are short cationic polypeptides whose antimicrobial activity is under intense investigation. In this review, we present a comprehensive summary of the AMPs with anti-Candida activity that have undergone successful preclinical or clinical trials. Their source, mode of action, and animal model of infection (or clinical trial) are presented. In addition, as so

SUBMITTER: Rodriguez-Castano GP 

PROVIDER: S-EPMC10053530 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature