Antileishmanial Activity of Cinnamic Acid Derivatives against Leishmania infantum.

ABSTRACT: Leishmania infantum is the etiological agent of visceral leishmaniasis (VL) in South America, the Mediterranean basin, and West and Central Asia. The most affected country, Brazil, reported 4297 VL cases in 2017. L. infantum is transmitted by female phlebotomine sand flies during successive blood meals. There are no validated vaccines to prevent the infection and the treatment relies on drugs that often present severe side effects, which justify the efforts to find new antileishmanial drugs. Cinnamic acid derivatives have shown several pharmacological activities, including antiparasitic action. Therefore, in the present study, the biological evaluation of cinnamic acid and thirty-four derivatives against L. infantum is reported. The compounds were prepared by several s

SUBMITTER: de Morais MC 

PROVIDER: S-EPMC10053546 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature