Rates of discontinuation and non-publication of upper and lower extremity fracture clinical trials.

ABSTRACT:

Purpose

To our knowledge, no study has quantified the rate of discontinuation and nonpublication of randomized controlled trials (RCTs) regarding upper and lower extremity fractures.

Methods

We searched ClinicalTrials.gov on September 9th, 2020, for phase 3 and 4 RCTs pertaining to upper and lower extremity fractures. Trial completion status was determined using records available on ClinicalTrials.gov. Publication status was determined using records on ClinicalTrials.gov and by searching PubMed (MEDLINE), Embase, and Google Scholar. We queried corresponding authors on trial status if a peer-reviewed publication was not identified.

Results

Our final analysis included 142 RCTs, of which 57 (40.1%) were discontinued and 71 (50%) were unpublished. Thirty-six (of 57, 63.2%

SUBMITTER: Shepard S 

PROVIDER: S-EPMC10053675 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature