Identification of Transporter Polymorphisms Influencing Metformin Pharmacokinetics in Healthy Volunteers.

ABSTRACT: For patients with type 2 diabetes, metformin is the most often recommended drug. However, there are substantial individual differences in the pharmacological response to metformin. To investigate the effect of transporter polymorphisms on metformin pharmacokinetics in an environment free of confounding variables, we conducted our study on healthy participants. This is the first investigation to consider demographic characteristics alongside all transporters involved in metformin distribution. Pharmacokinetic parameters of metformin were found to be affected by age, sex, ethnicity, and several polymorphisms. Age and SLC22A4 and SLC47A2 polymorphisms affected the area under the concentration-time curve (AUC). However, after adjusting for dose-to-weight ratio (dW), sex, age, and

SUBMITTER: Saiz-Rodriguez M 

PROVIDER: S-EPMC10053761 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature