A novel DNA methylation-related gene signature for the prediction of overall survival and immune characteristics of ovarian cancer patients.

ABSTRACT:

Background

Ovarian cancer (OC) is one of the most life-threatening cancers affecting women worldwide. Recent studies have shown that the DNA methylation state can be used in the diagnosis, treatment and prognosis prediction of diseases. Meanwhile, it has been reported that the DNA methylation state can affect the function of immune cells. However, whether DNA methylation-related genes can be used for prognosis and immune response prediction in OC remains unclear.

Methods

In this study, DNA methylation-related genes in OC were identified by an integrated analysis of DNA methylation and transcriptome data. Prognostic values of the DNA methylation-related genes were investigated through least absolute shrinkage and selection operator (LASSO) and Cox progression analyses. Immune

SUBMITTER: Wang S 

PROVIDER: S-EPMC10053775 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature