A Calcium- and GTP-Dependent Transglutaminase in Leishmania infantum.

ABSTRACT: While human and animal leishmaniasis affect several millions of people worldwide, L. infantum is the species responsible for visceral leishmaniasis in Europe, Middle East, and America. Antileishmanial drugs present issues associated with drug toxicity and increasing parasite resistance. Therefore, the study of this parasite with a focus on new potential drug targets is extremely useful. Accordingly, we purified and characterized a transglutaminase (TGase) from L. infantum promastigotes. While Tgases are known to be involved in cell death and autophagy, it appears that these functions are very important for parasites' virulence. For the first time, we showed a Ca²⁺- and GTP-dependent TGase in Leishmania corresponding to a 54 kDa protein, which was purified by

SUBMITTER: Almugadam SH 

PROVIDER: S-EPMC10053793 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature