Functional and Phenotypic Characterisations of Common Syngeneic Tumour Cell Lines as Estrogen Receptor-Positive Breast Cancer Models.

ABSTRACT: Estrogen receptor-positive breast cancers (ER⁺ BCas) are the most common form of BCa and are increasing in incidence, largely due to changes in reproductive practices in recent decades. Tamoxifen is prescribed as a component of standard-of-care endocrine therapy for the treatment and prevention of ER⁺ BCa. However, it is poorly tolerated, leading to low uptake of the drug in the preventative setting. Alternative therapies and preventatives for ER⁺ BCa are needed but development is hampered due to a paucity of syngeneic ER⁺ preclinical mouse models that allow pre-clinical experimentation in immunocompetent mice. Two ER-positive models, J110 and SSM3, have been reported in addition to other tumour models occasionally shown to express ER (for exampl

SUBMITTER: Lambouras M 

PROVIDER: S-EPMC10053941 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature