Glioblastoma-Derived Small Extracellular Vesicles: Nanoparticles for Glioma Treatment.

ABSTRACT: Glioblastoma (GBM), characterized by fast growth and invasion into adjacent tissue, is the most aggressive cancer of brain origin. Current protocols, which include cytotoxic chemotherapeutic agents, effectively treat localized disease; however, these aggressive therapies present side effects due to the high doses administered. Therefore, more efficient ways of drug delivery have been studied to reduce the therapeutic exposure of the patients. We have isolated and fully characterized small extracellular vesicles (EVs) from seven patient-derived GBM cell lines. After loading them with two different drugs, Temozolomide (TMZ) and EPZ015666, we observed a reduction in the total amount of drugs needed to trigger an effect on tumor cells. Moreover, we observed that GBM-derived small EVs, although

SUBMITTER: Araujo-Abad S 

PROVIDER: S-EPMC10054028 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature