Targeting Mitochondrial Therapy in the Regulation of HPV Infection and HPV-Related Cancers.

ABSTRACT: It has been previously proposed that some types of cancer cells reprogram their metabolic pathways, favoring the metabolism of glucose by aerobic glycolysis (Warburg effect) instead of oxidative phosphorylation, mainly because the mitochondria of these cells are damaged, thus displaying mitochondrial dysfunction. However, in several cancers, the mitochondria do not exhibit any dysfunction and are also necessary for the tumor's growth and maintenance. Remarkably, if the mitochondria are dysfunctional, specific processes associated with the release of cytochrome c (cyt c), such as apoptosis, are significantly impaired. In these cases, cellular biotherapies such as mitochondrial transplantation could restore the intrinsic apoptotic processes necessary for the elimination of cancers. On the ot

SUBMITTER: Cruz-Gregorio A 

PROVIDER: S-EPMC10054155 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature