Combining Three Tyrosine Kinase Inhibitors: Drug Monitoring Is the Key.

ABSTRACT: A combination of tyrosine kinase inhibitors (TKIs) is likely to be a therapeutic option for numerous oncological situations due to high frequency of oncogenic addiction and progress in precision oncology. Non-small cell lung cancer (NSCLC) represents a subtype of tumors for which oncogenic drivers are frequently involved. To the best of our knowledge, we report the first case of a patient treated with three different TKIs. Osimertinib and crizotinib were administered concurrently for an epidermal growth factor receptor (EGFR)-mutated NSCLC developing a MET amplification as a resistance mechanism to osimertinib. Simultaneously, imatinib was administered for a metastatic gastrointestinal stromal tumor. The progression-free survival was 7 months for both tumors with this trither

SUBMITTER: Thomas QD 

PROVIDER: S-EPMC10054357 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature