Proteomic Analysis of Female Synovial Fluid to Identify Novel Biomarkers for Osteoarthritis.

ABSTRACT: Osteoarthritis (OA) is a highly prevalent degenerative joint condition that disproportionately affects females. The pathophysiology of the disease is not well understood, which makes diagnosis and treatment difficult. Given the physical connection of synovial fluid (SF) with articular tissues, the SF's composition can reflect relevant biological modifications, and has therefore been a focus of research. Previously, we demonstrated that extracellular vesicles isolated from the synovial fluid of OA patients carry different cargo (protein and miRNA) in a sex-specific manner. Given the increased prevalence and severity of OA in females, this study aims to identify differential protein content within the synovial fluid of female OA and non-osteoarthritic (non-OA) patients. We found that several

SUBMITTER: Muller PR 

PROVIDER: S-EPMC10054440 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature