Design, Synthesis, and Antiviral Activities of New Benzotriazole-Based Derivatives.

ABSTRACT: Several human diseases are caused by enteroviruses and are currently clinically untreatable, pushing the research to identify new antivirals. A notable number of benzo[d][1,2,3]triazol-1(2)-yl derivatives were designed, synthesized, and in vitro evaluated for cytotoxicity and antiviral activity against a wide spectrum of RNA positive- and negative-sense viruses. Five of them (11b, 18e, 41a, 43a, 99b) emerged for their selective antiviral activity against Coxsackievirus B5, a human enteroviruses member among the Picornaviridae family. The EC₅₀ values ranged between 6 and 18.5 μM. Among all derivatives, compounds 18e and 43a were interestingly active against CVB5 and were selected to better define the safety profile on

SUBMITTER: Ibba R 

PROVIDER: S-EPMC10054465 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature