Bacteriolytic Potential of Enterococcus Phage iF6 Isolated from "Sextaphag^®" Therapeutic Phage Cocktail and Properties of Its Endolysins, Gp82 and Gp84.

ABSTRACT: The number of infections caused by antibiotic-resistant strains of bacteria is growing by the year. The pathogenic bacterial species Enterococcus faecalis and Enterococcus faecium are among the high priority candidate targets for the development of new therapeutic antibacterial agents. One of the most promising antibacterial agents are bacteriophages. According to the WHO, two phage-based therapeutic cocktails and two medical drugs based on phage endolysins are currently undergoing clinical trials. In this paper, we describe the virulent bacteriophage iF6 and the properties of two of its endolysins. The chromosome of the iF6 phage is 156,592 bp long and contains two direct terminal repeats, each 2108 bp long. Phylogenetically, iF6 belongs to the Schiekvirus genus, whos

SUBMITTER: Buzikov RM 

PROVIDER: S-EPMC10054541 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature