Increased HIV Incidence in Wuchereria bancrofti Microfilaria Positive Individuals in Tanzania.

ABSTRACT:

Background

Infections with Wuchereria bancrofti are associated with reduced immunity against concomitant infections. Indeed, our previous study described a 2.3-fold increased HIV incidence among individuals with W. bancrofti infection, as measured by the circulating filarial antigen of the adult worm. This new study aimed to retrospectively determine microfilariae status of the participants to assess if the previously described increased HIV susceptibility was associated with the presence of MF in the same cohort.

Methods

CFA positive but HIV negative biobanked human blood samples (n = 350) were analyzed for W. bancrofti MF chitinase using real time PCR.

Results

The PCR provided a positive signal in 12/350 (3.4%) samples. During four years

SUBMITTER: Mnkai J 

PROVIDER: S-EPMC10054595 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature