Realizing Both Antibacterial Activity and Cytocompatibility in Silicocarnotite Bioceramic via Germanium Incorporation.

ABSTRACT: The treatment of infective or potentially infectious bone defects is a critical problem in the orthopedic clinic. Since bacterial activity and cytocompatibility are always contrary factors, it is hard to have them both in one material. The development of bioactive materials with a good bacterial character and without sacrificing biocompatibility and osteogenic activity, is an interesting and valuable research topic. In the present work, the antimicrobial characteristic of germanium, GeO₂ was used to enhance the antibacterial properties of silicocarnotite (Ca₅(PO₄)₂SiO₄, CPS). In addition, its cytocompatibility was also investigated. The results demonstrated that Ge-CPS can effectively inhibit the proliferation of both Escherichia co

SUBMITTER: Ji Y 

PROVIDER: S-EPMC10054726 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature