Rapid Prototyping of Multi-Functional and Biocompatible Parafilm^®-Based Microfluidic Devices by Laser Ablation and Thermal Bonding.

ABSTRACT: In this paper, we report a simple, rapid, low-cost, biocompatible, and detachable microfluidic chip fabrication method for customized designs based on Parafilm^®. Here, Parafilm^® works as both a bonding agent and a functional membrane. Its high ultimate tensile stress (3.94 MPa) allows the demonstration of high-performance actuators such as microvalves and micropumps. By laser ablation and the one-step bonding of multiple layers, 3D structured microfluidic chips were successfully fabricated within 2 h. The consumption time of this method (~2 h) was 12 times less than conventional photolithography (~24 h). Moreover, the shear stress of the PMMA-Parafilm^®-PMMA specimens (0.24 MPa) was 2.13 times higher than that of the PDMS-PDMS specimens (0.08 MPa), and 0.56

SUBMITTER: Wei Y 

PROVIDER: S-EPMC10054776 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature