Selenium, Stroke, and Infection: A Threefold Relationship; Where Do We Stand and Where Do We Go?

ABSTRACT: Stroke is currently the second most common cause of death worldwide and a major cause of serious long-term morbidity. Selenium is a trace element with pleotropic effects on human health. Selenium deficiency has been associated with a prothrombotic state and poor immune response, particularly during infection. Our aim was to synthesize current evidence on the tripartite interrelationship between selenium levels, stroke, and infection. Although evidence is contradictory, most studies support the association between lower serum selenium levels and stroke risk and outcomes. Conversely, limited evidence on the role of selenium supplementation in stroke indicates a potentially beneficial effect of selenium. Notably, the relationship between stroke risk and selenium levels is bimodal rather than

SUBMITTER: Liampas A 

PROVIDER: S-EPMC10054895 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature