Functional connectomics reveals general wiring rule in mouse visual cortex.

ABSTRACT: Understanding the relationship between circuit connectivity and function is crucial for uncovering how the brain implements computation. In the mouse primary visual cortex (V1), excitatory neurons with similar response properties are more likely to be synaptically connected, but previous studies have been limited to within V1, leaving much unknown about broader connectivity rules. In this study, we leverage the millimeter-scale MICrONS dataset to analyze synaptic connectivity and functional properties of individual neurons across cortical layers and areas. Our results reveal that neurons with similar responses are preferentially connected both within and across layers and areas - including feedback connections - suggesting the universality of the 'like-to-like' connectivity across the visu

SUBMITTER: Ding Z 

PROVIDER: S-EPMC10054929 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature