Inhibitory input directs astrocyte morphogenesis through glial GABA _B R.

ABSTRACT: Communication between neurons and glia plays an important role in establishing and maintaining higher order brain function. Astrocytes are endowed with complex morphologies which places their peripheral processes in close proximity to neuronal synapses and directly contributes to their regulation of brain circuits. Recent studies have shown that excitatory neuronal activity promotes oligodendrocyte differentiation; whether inhibitory neurotransmission regulates astrocyte morphogenesis during development is unknown. Here we show that inhibitory neuron activity is necessary and sufficient for astrocyte morphogenesis. We found that input from inhibitory neurons functions through astrocytic GABA _B R and that its deletion in astrocytes results in a loss of morphological complexity ac

SUBMITTER: Cheng YT 

PROVIDER: S-EPMC10054985 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature